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José Manuel Cancio TrujilloAutor o coautor

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VitaminD supplementation for the prevention and treatment of COVID-19: a position statement from the Spanish Society of Geriatrics and Gerontology

Publicat a:Revista Española De Geriatría Y Gerontología: Órgano Oficial De La Sociedad Española De Geriatría Y Gerontología. 56 (3): 177 - 182 - 2021-01-01 56(3), DOI: 10.1016/j.regg.2021.02.001

Autors: Francisco José Tarazona Santabalbina; Leonor Cuadra; José Manuel Cancio Trujillo; Ferrán Roca Carbonell; Joan M Pérez-Castejón Garrote; Álvaro Casas Herrero; Nicolás Ignacio Martínez Velilla; José Antonio Serra Rexach; Francesc Formiga Pérez

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The coronavirus disease 2019 (COVID-19) produces severe respiratory symptoms such as bilateral pneumonia associated to a high morbidity and mortality, especially in patients of advanced age. Vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and dysregulation of the immune system. Vitamin D in modulates immune function too. Vitamin D receptor (VDR) is expressed by most immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells and the signalling of vitamin D and VDR together has an anti-inflammatory effect. Some studies have reported that vitamin D treatment could be useful for the prevention and treatment of COVID-19 because vitamin D plays an important role as a modulator of immunocompetence. Over the last few months, some studies have hypothesized the possible beneficial effect of vitamin D supplementation in patients with COVID-19 in order to improve the immune balance and prevent the hyperinflammatory cytokine storm. Some preliminary studies have already shown promising results with vitamin D supplementation in hospitalized COVID-19 patients. Vitamin D should be administered daily until adequate levels are achieved due to vitamin D behaves as a negative acute phase reactant (APR). Despite the lack of evidence on specific doses of vitamin D to treat COVID-19 in older adults, authors consider it is necessary to standardize the use in clinical practice. These recommendations advice supplement vitamin D in a protocoled fashion based on expert opinions, level of evidence 5.

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